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Détail de l'auteur
Auteur Cheryl Ngo
Documents disponibles écrits par cet auteur
Ajouter le résultat dans votre panier Affiner la rechercheA 3-year randomized clinical trial of misight lenses for myopia control / Paul Chamberlain in OVS : Optometry & Vision Science, vol. 96, 08 (Aout 2019)
[article]
in OVS : Optometry & Vision Science > vol. 96, 08 (Aout 2019)
Titre : A 3-year randomized clinical trial of misight lenses for myopia control Type de document : article de périodique Auteurs : Paul Chamberlain ; Sofia C. Peixoto-de-Matos ; Nicola Logan ; Cheryl Ngo ; Deborah Jones ; Graeme Young Année de publication : 2019 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Essai clinique
[Thésaurus Mesh]Lentilles de contact
[Thésaurus Mesh]Lentilles de contact hydrophiles
[Thésaurus Mesh]MyopieRésumé : SIGNIFICANCE Results of this randomized, double-masked clinical trial demonstrate the effectiveness of the MiSight soft contact lens in slowing myopia progression over multiple years.
PURPOSE The purpose of this study was to quantify the effectiveness of MiSight daily disposable soft contact lens in slowing the progression of juvenile-onset myopia.
METHODS Myopic children (spherical equivalent refraction, −0.75 to −4.00 D; astigmatism, <1.00 D) aged 8 to 12 years with no prior contact lens experience were enrolled in a 3-year, double-masked, randomized clinical trial at four investigational sites in four countries. Subjects in each group were matched for age, sex, and ethnicity and were randomized to either a MiSight 1-day contact lens (test) or Proclear 1-day (control; omafilcon A) and worn on a daily disposable basis. Primary outcome measures were the change in cycloplegic spherical equivalent refraction and axial length.
RESULTS Of the subjects enrolled, 75.5% (109/144) completed the clinical trial (53 test, 56 control). Unadjusted change in spherical equivalent refraction was −0.73 D (59%) less in the test group than in the control group (−0.51 ± 0.64 vs. –1.24 ± 0.61 D, P < .001). Mean change in axial length was 0.32 mm (52%) less in the test group than in the control group (0.30 ± 0.27 vs. 0.62 ± 0.30 mm, P < .001). Changes in spherical equivalent refraction and axial length were highly correlated (r = −0.90, P < .001). Over the course of the study, there were no cases of serious ocular adverse events reported. Four asymptomatic corneal infiltrative (one test, three control) events were observed at scheduled study visits.
CONCLUSIONS Results of this clinical trial demonstrate the effectiveness of the MiSight daily disposable soft contact lens in slowing change in spherical equivalent refraction and axial length.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Long-term Effect of Dual-focus Contact Lenses on Myopia Progression in Children: A 6-year Multicenter Clinical Trial / Paul Chamberlain in OVS : Optometry & Vision Science, vol.99, 03 (Mars 2022)
[article]
in OVS : Optometry & Vision Science > vol.99, 03 (Mars 2022)
Titre : Long-term Effect of Dual-focus Contact Lenses on Myopia Progression in Children: A 6-year Multicenter Clinical Trial Type de document : article de périodique Auteurs : Paul Chamberlain ; Arthur Bradley ; Baskar Arumugam ; David Hammond ; John McNally ; Nicola Logan ; Deborah Jones ; Cheryl Ngo ; Sofia C. Peixoto-de-Matos ; Chris Hunt ; Graeme Young Année de publication : 2022 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:M:Myopie:Myopie / prévention et contrôle
[Thésaurus Mesh]Enfant
[Thésaurus Mesh]Essais cliniques comme sujet
[Thésaurus Mesh]Évolution de la maladie
[Thésaurus Mesh]Lentilles de contact
[Thésaurus Mesh]ThérapeutiqueMots-clés : verres à double foyer Résumé : SIGNIFICANCE: Treatment of myopic children with a dual-focus soft contact lens (DFCL; MiSight 1 day) produced
sustained slowing of myopia progression over a 6-year period. Significant slowing was also observed in children
switched from a single vision control to treatment lenses (3 years in each lens).
PURPOSE: This study aimed to evaluate the effectiveness of DFCLs in sustaining slowed progression of juvenileonset myopia over a 6-year treatment period and assess myopia progression in children who were switched to a
DFCL at the end of year 3.
METHODS: Part 1 was a 3-year clinical trial comparing DFCLs with a control contact lens (Proclear 1 day) at four
investigational sites. In part 2, subjects completing part 1 were invited to continue for 3 additional years during
which all children were treated with MiSight 1 day DFCLs (52 and 56 from the initially treated [T6] and control
[T3] groups, respectively). Eighty-five subjects (45 [T3] and 40 [T6]) completed part 2. Cyclopleged spherical
equivalent refractive errors (SEREs) and axial lengths (ALs) were monitored, and a linear mixed model was used
to compare their adjusted change annually.
RESULTS: Average ages at part 2 baseline were 13.2 ± 1.3 and 13.0 ± 1.5 years for the T6 and T3 groups, respectively. Slowed myopia progression in the T6 group observed during part 1 was sustained throughout part 2
(mean ± standard error of the mean: change from baseline SERE [in diopters], −0.52 ± 0.076 vs. −0.51 ± 0.076;
change in AL [in millimeters], 0.28 ± 0.033 vs. 0.23 ± 0.033; both P > .05). Comparing progression rates in part
2 for the T6 and T3 groups, respectively, indicates that prior treatment does not influence efficacy (SERE,
−0.51 ± 0.076 vs. −0.34 ± 0.077; AL, 0.23 ± 0.03 vs. 0.18 ± 0.03; both P > .05). Within-eye comparisons of
AL growth revealed a 71% slowing for the T3 group (3 years older than part 1) and further revealed a small subset
of eyes (10%) that did not respond to treatment.
CONCLUSIONS: Dual-focus soft contact lenses continue to slow the progression of myopia in children over a
6-year period revealing an accumulation of treatment effect. Eye growth of the initial control cohort with DFCL
was slowed by 71% over the subsequent 3-year treatment period.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire