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Titre : | Pretreatment blood neutrophil/lymphocyte ratio is associated with metastasis and predicts survival in patients with pancreatic cancer |
Titre original : | Le ratio neutrophiles/lymphocytes préthérapeutique est associé au risque métastatique et prédit la survie chez les patients atteints de cancer du pancréas |
Type de document : | article de périodique |
Auteurs : | Jing Guo ; Mengwan Wu ; Lihong Guo ; Qiang Zuo |
Année de publication : | 2018 |
Article en page(s) : | p. 146-154 |
Note générale : | https://doi.org/10.1016/j.bulcan.2017.10.028
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Langues : | Français (fre) |
Descripteurs (mots clés) : | [Thésaurus Mesh]Facteurs de risque [Thésaurus Mesh]Granulocytes neutrophiles [Thésaurus Mesh]Infiltration par les neutrophiles [Thésaurus Mesh]Lymphocytes [Thésaurus Mesh]Marqueurs biologiques [Thésaurus Mesh]Métastase tumorale [Thésaurus Mesh]Pronostic [Thésaurus Mesh]Tumeurs du pancréas
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Mots-clés : | Granulocytes neutrophiles Infiltration par les neutrophiles Lymphocytes Pronostic Tumeurs du pancréas Facteurs de risque Marqueurs biologiques cancer du pancréas Ratio neutrophiles/lymphocytes métastase survie globale |
Résumé : | Background
The predictive value of systemic inflammatory markers has been explored in various types of cancer. In the present study, we aimed to investigate the association between pretreatment neutrophil/lymphocyte ratio (NLR) and tumor metastasis in pancreatic cancer, and the values of NLR as a prognostic factor of overall survival.
Methods
Clinical and laboratory data from 256 consecutive pancreatic cancer patients were analyzed retrospectively. The NLR was recorded before treatment and analyzed along with clinicopathological characteristics and overall survival of pancreatic cancer patients.
Results
Multivariate analysis revealed that pretreatment NLR (HR: 2.393; 95% CI: 1.326–4.320; P = 0.004) was an independent risk factor for distant metastasis. Furthermore, COX regression analysis showed that in addition to pretreatment NLR (HR: 1.871; 95% CI: 1.413–2.477; P < 0.001), metastasis and stage were independent prognostic factors.
Conclusion
Pretreatment NLR values were significantly associated with distant metastasis in pancreatic cancer patients. Higher NLR values were detected in metastatic disease and may be an independent prognostic factor of overall survival in pancreatic cancer patients. |
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