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Descripteurs (mots clés)
Thésaurus Mesh
> A > Anomalie de Pelger-Huët
Anomalie de Pelger-Huët
Autosomal dominant anomaly characterized by abnormal ovoid shape GRANULOCYTE nuclei and their clumping chromatin. Mutations in the LAMIN B receptor gene that results in reduced protein levels are associated with the disorder. Heterozygote individuals are healthy with normal granulocyte function while homozygote individuals occasionally have skeletal anomalies, developmental delay, and seizures.
GRANULOCYTE morphologic changes similar to the cells in familial Pelger-Huet anomoly. Granulocytes have abnormal bilobular morphology with hypercondensation due to drug therapy or secondary to diseases such as MYELODYSPLASTIC SYNDROMES and ACUTE MYELOID LEUKEMIA.
GRANULOCYTE morphologic changes similar to the cells in familial Pelger-Huet anomoly. Granulocytes have abnormal bilobular morphology with hypercondensation due to drug therapy or secondary to diseases such as MYELODYSPLASTIC SYNDROMES and ACUTE MYELOID LEUKEMIA.
Synonyme(s)
Syndrome de Pelger-HuëtRelation(s)
- voir aussi au terme générique : [Descripteurs (mots clés)] Troubles leucocytaires
- voir aussi au terme générique : [Descripteurs (mots clés)] Maladies génétiques congénitales
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