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Auteur Miguel Ortiz-Salvador
Documents disponibles écrits par cet auteur
Ajouter le résultat dans votre panier Affiner la rechercheCase Report: Tapioca Iris Melanoma: An Uncommon Presentation of an Uncommon Tumor / Clara Monferrer-Adsuara in OVS : Optometry & Vision Science, vol. 97, 11 (Novembre 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 11 (Novembre 2020)
Titre : Case Report: Tapioca Iris Melanoma: An Uncommon Presentation of an Uncommon Tumor Type de document : article de périodique Auteurs : Clara Monferrer-Adsuara ; Ramón Calvo-Andrés ; Javier Montero-Hernández ; LucÃa Mata-Moret ; Miguel Ortiz-Salvador ; Enrique Cervera-Taulet Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:T:Tumeurs de l'iris:Tumeurs de l'iris / anatomopathologie
[Thésaurus Mesh]:T:Tumeurs de l'iris:Tumeurs de l'iris / classification
[Thésaurus Mesh]Diagnostic différentiel
[Thésaurus Mesh]Tumeurs de l'iris
[Thésaurus HELB]:Paramédical:Cas cliniquePermalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Ipilimumab-induced Multisystem Autoimmune-like Toxicities Suggestive of Vogt-Koyanagi-Harada–like Syndrome / Clara Monferrer-Adsuara in OVS : Optometry & Vision Science, vol. 98, 11 (Novembre 2021)
[article]
in OVS : Optometry & Vision Science > vol. 98, 11 (Novembre 2021)
Titre : Ipilimumab-induced Multisystem Autoimmune-like Toxicities Suggestive of Vogt-Koyanagi-Harada–like Syndrome Type de document : article de périodique Auteurs : Clara Monferrer-Adsuara ; Laura Hernández-Bel ; MarÃa Luisa Hernández-Garfella ; Lidia RemolÃ-Sargues ; Miguel Ortiz-Salvador ; Verónica Castro-Navarro ; Enrique Cervera-Taulet Année de publication : 2021 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Auto-immunité
[Thésaurus Mesh]Effets secondaires indésirables des médicaments
[Thésaurus Mesh]Syndrome uvéo-méningo-encéphalique
[Thésaurus Mesh]Traitement médicamenteux
[Thésaurus Mesh]Uvéite
[Thésaurus HELB]:Paramédical:IpilimumabMots-clés : syndrome de Vogt-Koyanagi-Harada Résumé : SIGNIFICANCE
The emergence of new cancer therapies has dramatically improved outcomes in metastatic melanoma. Immune checkpoint inhibitors have been the most effective treatment. Although, as a direct consequence of the immune dysregulation induced by them, adverse effects termed immune-related adverse events are observed in more than 60% of the patients.
PURPOSE
We describe the clinical presentation of Vogt-Koyanagi-Harada–like syndrome in a patient with concomitant systemic melanoma treatment with ipilimumab, a cytotoxic T lymphocyte–associated antigen 4 blocker.
METHODS
This study aimed to report a case of ipilimumab-induced vitritis, papillitis, and skin and auditory signs suggestive of Vogt-Koyanagi-Harada–like syndrome.
CASE REPORT
A 64-year-old woman with metastatic melanoma presented with bilateral blurred vision and hearing loss upon completion of three cycles of treatment with ipilimumab. Ophthalmologic examination revealed a bilateral granulomatous uveitis with intense vitritis and papillitis. The result of optical coherence tomography was normal, and fluorescein angiography confirmed the bilateral papillary edema. Ipilimumab was withdrawn, and treatment with oral and systemic steroids led to a rapid improvement in the ophthalmologic and auditory manifestations. Three months after initial presentation, the patient developed vitiligo and poliosis.
CONCLUSIONS
Vogt-Koyanagi-Harada–like syndrome can develop in the process of immunological deregulation by ipilimumab in the treatment of metastatic melanoma and can correlate temporally with the efficacy of the drug in tumor regression. These observations may help elucidate the underlying mechanism of Vogt-Koyanagi-Harada syndrome as well as the relation between tumor-associated tolerance and autoimmunity.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Nutritional and Toxic Optic Neuropathy: A Diagnostic Dilemma : Case Report / Clara Monferrer-Adsuara in OVS : Optometry & Vision Science, vol. 97, 07 (Juillet 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 07 (Juillet 2020)
Titre : Nutritional and Toxic Optic Neuropathy: A Diagnostic Dilemma : Case Report Type de document : article de périodique Auteurs : Clara Monferrer-Adsuara ; Carolina GarcÃa-Villanueva ; LucÃa Mata-Moret ; Miguel Ortiz-Salvador ; Lidia RemolÃ-Sargues ; Enrique Cervera-Taulet Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Atteintes du nerf optique
[Thésaurus Mesh]Maladies de carence
[Thésaurus Mesh]Régime alimentaire
[Thésaurus Mesh]Toxines biologiques
[Thésaurus Mesh]Vision oculaire
[Thésaurus Type de publication]Présentations de casRésumé : SIGNIFICANCE
Nutritional and toxic optic neuropathies are rare disorders characterized by visual impairment due to optic nerve damage by a toxin, usually with coexisting nutritional deficiencies. Its pathophysiology is still unclear, and multiple mechanisms implicated act synergistically to bring about this condition. The decline in its incidence and its confusing clinical appearance make diagnosing nutritional and toxic optic neuropathies challenging.
PURPOSE
This is an observational clinical case report of an atypical clinical case of a nutritional and toxic optic neuropathy with a subacute presentation and papilledema at the time of diagnosis. The patient provided written informed consent for medical information and images to be published.
CASE REPORT
A 47-year-old man presented with progressive, painless bilateral decrease in central vision over 15 days. The patient had a long-standing history of alcohol abuse and was a heavy smoker. The examination revealed dyschromatopsia, 20/400 visual acuity on both eyes, and no relative afferent pupillary defect. Funduscopy revealed bilateral papilledema. A visual field test showed generalized depression with centrocecal involvement in the left eye. Laboratory studies evidenced decreased vitamin B 12 /B 1 and red blood cell folate levels, increased acute phase reactants, hypertransaminasemia, and macrocytic anemia. Serologies and methanol in urine were negative. After the discontinuation of tobacco use and alcohol accompanied by vitamin supplementation, our patient's visual field, visual acuity, and papilledema improved remarkably. After 5 months, visual acuity and funduscopy were normal.
CONCLUSIONS
Although some hallmark signs were visible in this case, its subacute presentation and the presence of papilledema at diagnosis caused some diagnostic uncertainty. Nutritional and toxic optic neuropathy is a rare and challenging diagnosis because of a lack of biomarkers. Eye care clinicians should consider nutritional and toxic optic neuropathies to prevent severe and irreversible visual damage resulting from underdiagnosis and mismanagement.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire