Titre : | Impact of Cardiovascular Disease Risk Factors on Subfoveal Choroidal Thickness by Enhanced-depth Spectral Domain Optical Coherence Tomography |
Type de document : | article de périodique |
Auteurs : | Rachel Druckenbrod ; Baharak Asefzadeh ; Anne Bertolet |
Année de publication : | 2020 |
Langues : | Français (fre) |
Descripteurs (mots clés) : | [Thésaurus Mesh]:M:Maladies cardiovasculaires:Maladies cardiovasculaires / diagnostic [Thésaurus Mesh]Choroïde [Thésaurus Mesh]Comorbidité [Thésaurus Mesh]Maladies cardiovasculaires [Thésaurus Mesh]Maladies de la choroïde [Thésaurus Mesh]Marqueurs biologiques [Thésaurus Mesh]Tomographie par cohérence optique [Thésaurus Mesh]Uvée [Thésaurus HELB]:Optique:Épaisseur choroïdienne fovéolaire
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Mots-clés : | cardiovascular diseases comorbidity choroid diseases tomography, optical coherence Biomarkers |
Résumé : | SIGNIFICANCE: Risk stratification plays a large role in cardiovascular disease (CVD) management. Spectral-domain
optical coherence tomography (SD-OCT) allows for noninvasive analysis of the ophthalmic vasculature, with potential
for systemic disease surveillance. Subfoveal choroidal thickness (SFCT) may serve as a marker for CVD risk and
play a role in risk stratification.
PURPOSE: This study aimed to explore the association of major CVD risk factors CVD on SFCT measured from
SD-OCT images in a general population of U.S. veterans.
METHODS: One hundred fifty veterans were prospectively recruited at the Jamaica Plain VA Hospital (Boston, MA).
A total of 143 participants were included in the final analysis. The SFCT was manually measured from Spectralis
SD-OCT macular scans, and medical chart review was analyzed for CVD data. The SFCT measurements were correlated with CVD risk factors and CVD clinical makers while controlling for age and refractive error. Mean differences
in SFCT between those with and without CVD risk factors were analyzed.
RESULTS: In multivariate analysis, diabetes diagnosis was independently associated with thinner subfoveal choroid (P = .001) and hypertension and hyperlipidemia with thicker subfoveal choroid (P = .006 and P = .05). After
adjusting for age and refractive error, veterans with diabetes had thinner choroids than those without (P = .02), and
veterans with hypertension and hyperlipidemia had thicker choroids than those without, although these differences
did not reach statistical significance (P = .07 and P = .1).
CONCLUSIONS: Comorbid risk factors for CVD are independently associated with optical coherence tomography–
derived measurements of subfoveal choroidal thickness in a vasculopathic population of U.S. veterans, and there
are detectable differences in subfoveal choroidal thickness between groups with and without CVD risk factors.
Larger studies with adequate controls and longitudinal design are necessary to assess the clinical role of SFCT
measurements in CVD risk analysis.
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