Titre : | Antimicrobial Photodynamic Therapy in Infected Diabetic Foot Ulcers: A Multicenter Preliminary Experience |
Type de document : | article de périodique |
Auteurs : | Matteo Monami ; Alessia Scatena ; Michael Schlecht ; Ralf Lobmann ; Letizia Landi ; Lucia Ricci ; Edoardo Mannucci |
Année de publication : | 2020 |
Langues : | Anglais (eng) |
Descripteurs (mots clés) : | [Thésaurus Mesh]:I:Infection de plaie:Infection de plaie / thérapie [Thésaurus Mesh]:U:Ulcère du pied:Ulcère du pied / thérapie [Thésaurus Mesh]Cicatrisation de plaie [Thésaurus Mesh]Comorbidité [Thésaurus Mesh]Photothérapie dynamique [Thésaurus Mesh]Pied diabétique [Thésaurus Mesh]Résistance bactérienne aux médicaments [Thésaurus Mesh]Ulcère du pied
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Mots-clés : | drug resistance, bacterial comorbidity foot ulcer photochemotherapy wound infection, therapeutic's phtalocyanine wound healing |
Résumé : | Background: The increasing resistance of bacteria to antibiotics and the frequency of comorbid conditions of patients make the treatment of diabetic foot infections problematic. In this context, photodynamic therapy could be a useful tool to treat infected wounds. The aim of this study was to evaluate the effect of repeated applications of a phthalocyanine derivative (RLP068) on the bacterial load and on the healing process.
Methods: The present analysis was performed on patients with clinically infected ulcers who had been treated with RLP068. A sample for microbiological culture was collected at the first visit before and immediately after the application of RLP068 on the ulcer surface, and the area was illuminated for 8 minutes with a red light. The whole procedure was repeated three times per week at two centers (Florence and Arezzo, Italy) (sample A), and two times per week at the third center (Stuttgart, Germany) (sample B) for 2 weeks.
Results: Sample A and sample B were composed of 55 and nine patients, respectively. In sample A, bacterial load decreased significantly after a single treatment, and the benefit persisted for 2 weeks. Similar effects of the first treatment were observed in sample B. In both samples, the ulcer area showed a significant reduction during follow-up, even in patients with ulcers infected with gram-negative germs or with exposed bone.
Conclusions: RLP068 seems to be a promising topical wound management procedure for the treatment of infected diabetic foot ulcers. |
Note de contenu : | Matteo Monami, Alessia Scatena, Michael Schlecht, Ralf Lobmann, Letizia Landi, Lucia Ricci and Edoardo Mannucci |
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