Titre : | The Use of Autologous Serum Eye Drops after Epithelium-off Corneal Collagen Crosslinking |
Type de document : | article de périodique |
Auteurs : | Ahmet Kirgiz ; Mehmet Orcun Akdemir ; Ahu Yilmaz ; Havva Kaldirim ; Kursat Atalay ; Senay Asik Nacaroglu |
Année de publication : | 2020 |
Langues : | Français (fre) |
Descripteurs (mots clés) : | [Thésaurus Mesh]:D:Douleur postopératoire:Douleur postopératoire / traitement médicamenteux [Thésaurus Mesh]:K:Kératocône:Kératocône / chirurgie [Thésaurus Mesh]:K:Kératocône:Kératocône / thérapie [Thésaurus Mesh]Kératocône [Thésaurus Mesh]Solutions ophtalmiques [Thésaurus HELB]:Optique:crosslinking du collagène cornéen
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Mots-clés : | collyre sérique autologue |
Résumé : | SIGNIFICANCE: After epithelium-off crosslinking (CXL), epithelial closure time and post-operative pain are an important issue in terms of possible complications and patient comfort. We report a prospective randomized study about the use of autologous serum eye drops after CXL. PURPOSE: This study aims to evaluate the effect of autologous serum eye drops on epithelial healing and postoperative pain after CXL. METHODS: Sixty patients diagnosed as having progressive keratoconus and treated with accelerated CXL (9 mW/ cm2 for 10 minutes) randomly received 20% autologous serum eye drops (autologous serum group, n = 30) or artificial tears (control group, n = 30). Patients were evaluated every day after the surgery, and the day of epithelial closure was recorded. All patients were asked to report the maximum pain level using the Wong-Baker FACES Pain Rating Scale at the end of each day until the epithelial closure was completed. The change in topographic parameters and haze were recorded at 6 months. RESULTS: The mean epithelial closure time was significantly lower in the autologous serum group than in the control group (2.37 ± 0.49 and 2.67 ± 0.47 days, respectively; P = .02). There was a statistically significant difference between the pain scores in the first and second days of surgery between the two groups (first-day autologous serum autologous serum group: 2.80 ± 0.66 and control group: 3.50 ± 0.82, P = .01; second-day autologous serum group: 1.73 ± 0.69 and control group: 2.20 ± 0.76, P = .02). Pre-operative and post-operative topographic parameters and haze at 6 months were similar between the two groups (P > .05 for all). CONCLUSIONS: Use of autologous serum eye drops after CXL accelerates epithelial healing and reduces postoperative pain. Shortening the duration of epithelial closure would be beneficial in reducing possible complications and increasing patient comfort. |
En ligne : | https://journals.lww.com/optvissci/Fulltext/2020/04000/The_Use_of_Autologous_Ser [...] |
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