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Détail de l'auteur
Auteur Maria Markoulli
Documents disponibles écrits par cet auteur
Ajouter le résultat dans votre panier Affiner la rechercheImpact of Peripheral and Corneal Neuropathy on Markers of Ocular Surface Discomfort in Diabetic Chronic Kidney Disease / Kofi Asiedu in OVS : Optometry & Vision Science, vol. 99, 11 (Novembre 2022)
[article]
in OVS : Optometry & Vision Science > vol. 99, 11 (Novembre 2022)
Titre : Impact of Peripheral and Corneal Neuropathy on Markers of Ocular Surface Discomfort in Diabetic Chronic Kidney Disease Type de document : article de périodique Auteurs : Kofi Asiedu ; Roshan Dhanapalaratnam ; Arun Krishnan ; Natalie Kwai ; Ann Poynten ; Maria Markoulli Année de publication : 2022 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Cornée
[Thésaurus Mesh]Défaillance rénale chronique
[Thésaurus Mesh]Diabète de type 2
[Thésaurus Mesh]Douleur
[Thésaurus Mesh]Étude comparative
[Thésaurus Mesh]Troubles de la visionMots-clés : affectation du nerf cornéen marqueurs de l'homéostasie Résumé : SIGNIFICANCE: There is a reduction in corneal nerve fiber density and length in type 2 diabetes mellitus with chronic kidney disease compared with type 2 diabetes mellitus alone; however, this difference does not result in worse ocular surface discomfort or dry eye disease. PURPOSE: This study aimed to determine the clinical impact of corneal nerve loss on ocular surface discomfort and markers of ocular surface homeostasis in people with type 2 diabetes mellitus without chronic kidney disease (T2DM–no CKD) and those with type 2 diabetes mellitus with concurrent chronic kidney disease (T2DM-CKD). METHODS: Participants were classified based on estimated glomerular filtration rates into two groups: T2DM-CKD (n = 27) and T2DM–no CKD (n = 28). RESULTS: There was a significant difference between the T2DM-CKD and T2DM–no CKD groups in corneal nerve fiber density (14.9 ± 8.6 and 21.1 ± 7.1 no./mm2 , respectively; P = .005) and corneal nerve fiber length (10.0 ± 4.6 and 12.3 ± 3.7 mm/mm2 , respectively; P = .04). Fluorescein tear breakup time was significantly reduced in T2DM-CKD compared with T2DM–no CKD (8.1 ± 4.4 and 10.7 ± 3.8 seconds, respectively; P = .01), whereas ocular surface staining was not significantly different (3.5 ± 1.7 and 2.7 ± 2.3 scores, respectively; P = .12). In terms of ocular surface discomfort, there were no significant differences in the ocular discomfort score scores (12.5 ± 11.1 and 13.6 ± 12.1, respectively; P = .81) and Ocular Pain Assessment Survey scores (3.3 ± 5.4 and 4.3 ± 6.1, respectively; P = .37) between the T2DM-CKD and T2DM–no CKD. CONCLUSIONS: The current study demonstrated that corneal nerve loss is greater in T2DM-CKD than in T2DM–no CKD. However, these changes do not impact ocular surface discomfort or markers of ocular surface homeostasis. Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire The Relationship between Corneal Nerve Morphology and Inflammatory Mediators and Neuropeptides in Healthy Individuals / Maria Markoulli in OVS : Optometry & Vision Science, vol. 97, 03 (mars 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 03 (mars 2020)
Titre : The Relationship between Corneal Nerve Morphology and Inflammatory Mediators and Neuropeptides in Healthy Individuals Type de document : article de périodique Auteurs : Maria Markoulli ; Luisa H. Colorado ; Katie Edwards Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Comorbidité
[Thésaurus Mesh]Complications du diabète
[Thésaurus Mesh]Maladies de l'oeil
[Thésaurus Mesh]Neuropeptides
[Thésaurus Mesh]Phénomènes physiologiques du système nerveux
[Thésaurus Mesh]Systèmes sanguin et immunitaire
[Thésaurus HELB]:Optique:Film lacrymalMots-clés : nerfs cornéens Résumé : SIGNIFICANCE: This study set out to explore the relationship between the ocular surface immune and nervous systems by exploring corneal nerve structure and the presence of inflammatory mediators and neuropeptides in the tear film. PURPOSE: The purpose of this study was to determine the association between corneal nerve morphology and tear film inflammatory mediators and a neuropeptide in healthy individuals. METHODS: Flush tears were collected from both eyes of 21 healthy participants aged 39.7 ± 9.9 years (10 females, 11 males) and analyzed for substance P, matrix metalloproteinase-9, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), tumor necrosis factor α, and interleukin 6. In vivo central corneal confocal microscopy was performed on the right eye, and eight images were captured. Variables measured were corneal nerve fiber length (CNFL), corneal nerve density (CNFD), corneal nerve branch density, fiber total branch density, corneal nerve fiber area, corneal nerve fiber width (CNFW), and corneal nerve fractal dimension (CNFrac). For each eye, the average across the images and the maximum and minimum values were determined for each variable. Pearson correlation analysis was performed to test for associations. RESULTS: Substance P correlated with CNFrac (max) (r = −0.48, P = .03) and CNFW (min) (r = −0.52, P = .02). TIMP-1 correlated with CNFD (average) (r = −0.53, P = .03), CNFL (average) (r = −0.49, P = .05), CNFrac (max) (r = −0.49, P = .05), and CNFD (min) (r = −0.55, P = .02). Interleukin 6 correlated with CNFW (average) (r = −0.49, P = .05), the standard deviation of CNFL (r = −0.51, P = .04), CNFL (max) (r = −0.50, P = .04), CNFrac (max) (r = −0.50, P = .04), and CNFW (min) (r = −0.55, P = .02). Tumor necrosis factor α, matrix metalloproteinase-9, and its ratio with TIMP-1 did not correlate with any corneal nerve parameters. CONCLUSIONS: Both inflammatory mediators and neuropeptides correlated with measures of corneal nerve morphology, supporting the link between the inflammatory and nervous systems En ligne : https://journals.lww.com/optvissci/Fulltext/2020/03000/The_Relationship_between_ [...] Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
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