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Auteur Rohan Chawla
Documents disponibles écrits par cet auteur
Ajouter le résultat dans votre panier Affiner la rechercheEvaluation of the Levels of Low-dose Topical Atropine (0.01%) in Aqueous and Vitreous Humor in Human Eyes / Prakash Kumar in OVS : Optometry & Vision Science, vol. 100, 08 (Aout 2023)
[article]
in OVS : Optometry & Vision Science > vol. 100, 08 (Aout 2023)
Titre : Evaluation of the Levels of Low-dose Topical Atropine (0.01%) in Aqueous and Vitreous Humor in Human Eyes Type de document : article de périodique Auteurs : Prakash Kumar ; Rohit Saxena ; Rebika Dhiman ; Swati Phuljhele ; Vinod Kumar ; Rohan Chawla ; Thirumurthy Velpandian Année de publication : 2023 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:M:Myopie:Myopie / thérapie
[Thésaurus Mesh]Atropine
[Thésaurus Mesh]Humeur aqueuse
[Thésaurus Mesh]Projets pilotesMots-clés : humeur aqueuse et vitrée de l'oeil pénétration Résumé : SIGNIFICANCE
This is the first human study that confirmed penetration of 0.01% topical atropine in aqueous and vitreous humor in live human eyes. This supports the possible mode of action of atropine via posterior ocular structures. This knowledge will help improve the outcomes in myopia management.
PURPOSE
The purpose of this study was to evaluate penetration of low-dose atropine 0.01% in aqueous and vitreous humor.
METHODS
In this cross-sectional interventional pilot study, 48 cataract cases were divided into four groups (12 each), and 30 epiretinal membrane/macular hole cases were divided into three groups (10 each). One drop of 0.01% atropine was put in the eye to be operated. Aqueous humor samples were taken from patients undergoing cataract surgery at 60 ± 15 minutes in group 1, 120 ± 15 minutes in group 2, 240 ± 15 minutes in group 3, and 360 ± 15 minutes in group 4. Vitreous humor samples were taken from patients undergoing vitreoretinal surgery for epiretinal membrane/macular hole at 120 ± 15 minutes in group 1, 240 ± 15 minutes in group 2, and 360 ± 15 minutes in group 3. The assay of atropine was performed using liquid chromatography–mass spectrometry.
RESULTS
Median concentrations of atropine in aqueous samples were 1.33 ng/mL (min-max, 0.6 to 6.46 ng/mL; interquartile range [IQR], 3.05 ng/mL) at 60 minutes, 2.60 ng/mL (min-max, 0.63 to 4.62 ng/mL; IQR, 1.97 ng/mL) at 120 minutes, 1.615 ng/mL (min-max, 0.1 to 3.74 ng/mL; IQR, 1.62 ng/mL) at 240 minutes, and 1.46 ng/mL (min-max, 0.47 to 2.80 ng/mL; IQR, 1.73 ng/mL) at 360 minutes, and those in vitreous samples were 0.102 ng/mL (min-max, 0 to 0.369 ng/mL; IQR, 0.366 ng/mL) at 120 minutes, 0.1715 ng/mL (min-max, 0 to 0.795 ng/mL; IQR, 0.271 ng/mL) at 240 minutes, and 0.2495 ng/mL (min-max, 0 to 0.569 ng/mL; IQR, 0.402 ng/mL) at 360 minutes, respectively.
CONCLUSIONS
Measurable concentration of low-dose topical atropine (0.01%) was noted in aqueous and vitreous humor after instillation of a single drop of low-dose atropine. Muscarinic receptors located in the posterior segment such as the choroid and retina could be the possible site of action of low-dose atropine in myopia.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Peripapillary Retinal and Choroidal Perfusion in Nonarteritic Ischemic Optic Neuropathy Using Optical Coherence Tomography Angiography / Rebika Dhiman in OVS : Optometry & Vision Science, vol. 97, 08 (Aout 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 08 (Aout 2020)
Titre : Peripapillary Retinal and Choroidal Perfusion in Nonarteritic Ischemic Optic Neuropathy Using Optical Coherence Tomography Angiography Type de document : article de périodique Auteurs : Rebika Dhiman ; Rohan Chawla ; Shorya Vardhan Azad ; Pawan Kumar ; Vinay Gupta ; Atul Kumar ; Rohit Saxena Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Angiographie
[Thésaurus Mesh]Collecte de données
[Thésaurus Mesh]Diagnostic par imagerie
[Thésaurus Mesh]Tomographie par cohérence optique
[Thésaurus HELB]:Paramédical:insuffisance vasculaire
[Thésaurus HELB]:Paramédical:neuropathie optique ischémique non artéritiqueRésumé : SIGNIFICANCE: Nonarteritic ischemic optic neuropathy (NAION) has been linked with vascular insufficiency, although the pathophysiology remains elusive. Optical coherence tomography angiography (OCTA) is a promising
technology that noninvasively evaluates optic disc perfusion and that may help to characterize peripapillary vascular changes in NAION.
PURPOSE: This study aimed to evaluate peripapillary vascularity in NAION eyes and to compare it with fellow unaffected eyes and healthy control eyes using OCTA.
METHODS: In this cross-sectional study, OCTA of the optic nerve head was obtained in 10 nonacute unilateral
NAION and 12 healthy age-matched controls using ZEISS Angioplex. Quantitative analysis of peripapillary retinal
and choroidal vascularity of NAION eyes was done using the instrument's inbuilt algorithm and ImageJ software
and compared with fellow and control eyes.
RESULTS: Mean total peripapillary superficial retinal vessel and perfusion density as calculated by the instrument
was significantly reduced in NAION eyes compared with fellow eyes (13.93 ± 4.27 mm−1
/0.36 ± 0.07 for NAION
eyes; 17.77 ± 1.26 mm−1
/0.43 ± 0.08 for fellow eyes; P = .01/P = .05). Using the ImageJ software technique, the
mean superficial retinal perfusion was found to be significantly reduced in NAION eyes (0.17 ± 0.07) compared
with fellow eyes (0.25 ± 0.06; P < .01) and control eyes (0.25 ± 0.04; P < .01). At the level of choriocapillaris,
it was not significantly affected in NAION eyes (0.37 ± 0.13) versus fellow (0.34 ± 0.14; P = .1) and control eyes
(0.31 ± 0.34; P = .83). Analysis with the two techniques yielded differing results: the ImageJ analysis technique
found a 32% reduction in superficial retinal perfusion in NAION eyes, whereas the instrument's inbuilt algorithm
found a 16% reduction compared with fellow and control eyes (P ≤.01).
CONCLUSIONS: Peripapillary vascularity can be estimated both at the retinal and choroidal levels using ImageJ
software to analyze OCTA images. Retinal peripapillary vascularity is compromised in NAION eyes, but vascularity
is not significantly affected at the choroidal level.Note de contenu :
Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
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