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Auteur Debby Yeung
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Ajouter le résultat dans votre panier Affiner la rechercheComparative Analysis of Tear Proteins in Keratoconic Scleral Lens Wearers with Variation in Limbal Clearance / Debby Yeung in OVS : Optometry & Vision Science, vol. 98, 02 (Février 2021)
[article]
in OVS : Optometry & Vision Science > vol. 98, 02 (Février 2021)
Titre : Comparative Analysis of Tear Proteins in Keratoconic Scleral Lens Wearers with Variation in Limbal Clearance Type de document : article de périodique Auteurs : Debby Yeung ; Paul J. Murphy ; Luigina Sorbara Année de publication : 2021 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Cytokines
[Thésaurus Mesh]Inflammation
[Thésaurus Mesh]Kératocône
[Thésaurus Mesh]Peptide hydrolases
[Thésaurus HELB]:Optique:Film lacrymal
[Thésaurus HELB]:Optique:lentilles scléralesRésumé : SIGNIFICANCE
Cytokine and protease analysis revealed relative changes in the post-lens tear film of scleral lenses with low and high limbal clearances. Results from this study indicate that midperipheral lens fit is an important fitting feature that can impact the inflammatory response of a keratoconic eye.
PURPOSE
The purpose of this study was to investigate changes in levels of inflammatory mediators in the post-lens tear film of keratoconic scleral lens wearers with varying limbal clearance designs.
METHODS
Twenty-two keratoconic eyes were fitted with two sets of scleral lenses that were consistent in lens diameter and central sagittal depth but varied in limbal clearance by approximately 50 μm. Lenses were worn in a randomly assigned order for a 2-week period each. At each follow-up visit, immediately after lens removal, tear samples were collected with a microcapillary tube (10 μL, 0.5 mm in diameter) from the bowl of the inverted scleral lens. Tear cytokine and protease analysis was performed using a multiplex electrochemiluminescent array (Meso Scale Discovery, Rockville, MD) instrument. Levels of interleukins 1, 6, and 8; tumor necrosis factor α; and matrix metalloproteinases 1 and 9 were compared and analyzed.
RESULTS
Levels of interleukin 1β, tumor necrosis factor α, and matrix metalloproteinase 1 increased with high limbal clearance (P = .01, .006, and .02, respectively). No change in interleukins 6 and 8 levels was found (P > .05). A decrease in matrix metalloproteinase 9 was noted in post-lens tear film of scleral lenses with high limbal clearance (P = .10).
DISCUSSION
Relative changes in the cytokine and protease levels were found when comparing low and high limbal clearance, indicating that the midperipheral lens fit is an important feature that can impact the inflammatory response of the keratoconic eye.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Objective and Subjective Evaluation of Clinical Performance of Scleral Lens with Varying Limbal Clearance in Keratoconus / Debby Yeung in OVS : Optometry & Vision Science, vol. 97, 09 (Septembre 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 09 (Septembre 2020)
Titre : Objective and Subjective Evaluation of Clinical Performance of Scleral Lens with Varying Limbal Clearance in Keratoconus Type de document : article de périodique Auteurs : Debby Yeung ; Paul J. Murphy ; Luigina Sorbara Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus HELB]:Optique:lentilles sclérales
[Thésaurus HELB]:Optique:port de lentilles de contact
[Thésaurus HELB]:Paramédical:CONFORT
[Thésaurus HELB]:Paramédical:Étude évaluation
[Thésaurus Mesh]Vision oculaireRésumé : SIGNIFICANCE: This study evaluates how limbal clearance (LC) may impact the clinical performance of scleral lenses based on subjective response on comfort and ocular responses. Limbal zone designs in scleral lenses might affect the integrity of the limbal epithelial tissue as a result of a combined hypoxic and compression-related etiology. PURPOSE: This study aimed to investigate the clinical performance and ocular and subjective responses to the wear of scleral lenses having varying LC. METHODS: Lenses with varying LC with a difference of 50 μm were fitted on and compared among keratoconic participants. The lenses were worn during a 2-week period. Visual analog scales concerning subjective comfort were completed. Ocular surface findings including hyperemia, limbal staining, and corneal swelling were compared. RESULTS: Participants reported greater comfort achieved with high LC. No difference in limbal and bulbar hyperemia was found (P > .05). Corneal response to scleral lens wear with both low and high LCs seems to result in similar perilimbal staining and negative corneal staining. An increase in corneal pachymetric values was noted at the central and peripheral cornea, with no difference between low- and high-LC lenses (all, P < .05). Quadrant-specific analysis indicated that all meridians at both 6 and 8 mm were increased for the low-LC lenses (all, P < .05) and only the temporal region for the high-LC lenses (P = .02). CONCLUSIONS: Limbal clearance may play an important role in subjective performance in scleral lenses but does not impact the degree of hyperemia in either the limbal or bulbar region. Although low LC might result in more compression-related changes to ocular surface, high LC is associated with greater comfort and greater edematous changes. Limbal zone designs in scleral lenses might affect the integrity of the limbal epithelial tissue as a result of a combined hypoxic and compression-related etiology Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire