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Auteur Longqian Liu
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Ajouter le résultat dans votre panier Affiner la rechercheAltered Expression of GJD2 Messenger RNA and the Coded Protein Connexin 36 in Negative Lens–induced Myopia of Guinea Pigs / Qiurong Zhu in OVS : Optometry & Vision Science, vol. 97, 12 (Décembre 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 12 (Décembre 2020)
Titre : Altered Expression of GJD2 Messenger RNA and the Coded Protein Connexin 36 in Negative Lens–induced Myopia of Guinea Pigs Type de document : article de périodique Auteurs : Qiurong Zhu ; Guoyuan Yang ; Bingjie Chen ; Fengyang Liu ; Xia Li ; Longqian Liu Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Croissance et développement
[Thésaurus Mesh]Expérimentation animale
[Thésaurus Mesh]Myopie
[Thésaurus Mesh]Oeil
[Thésaurus Mesh]RétineMots-clés : gène GJD2 protéine Cx36 Résumé : SIGNIFICANCE: Decreased expression of the retinal GJD2 gene messenger RNA (mRNA) and connexin 36 (Cx36) protein in the guinea pig negative lens–induced myopia (LIM) model suggests their involvement in local retinal circuits regulating eye growth. PURPOSE: Previous studies suggest that the GJD2 gene and Cx36 protein encoded by the GJD2 gene play important roles in retinal signaling pathways and eye development. The aim of this study was to investigate the changes in GJD2 mRNA and Cx36 protein expression in the guinea pig lens-induced myopia model. METHODS: Four-week-old guinea pigs were randomly divided into two groups. Animals in the experimental group were fitted with monocular −10 D lenses; and animals in the control group, with monocular plano lenses. Biometric measurements, including the spherical equivalent refractive error and axial length, were monitored. Animals were killed after 0, 1, 2, and 3 weeks of treatment, and their retinas were isolated. Retinal GJD2 mRNA and Cx36 protein expression levels were assessed by quantitative real-time polymerase chain reaction and Western blot analysis, respectively. RESULTS: Spherical equivalent refractive error values indicated that negative lens–treated eyes became significantly more myopic than plano lens–treated eyes (P = .001), consistent with their longer axial lengths compared with those of control eyes. Both GJD2 mRNA and Cx36 protein expression levels were decreased in the retinas of negative lens–treated eyes compared with levels in the retinas of plano lens–treated eyes, although there were differences in the timing; GJD2 mRNA, levels were significantly decreased after 1 and 2 weeks of treatment (P = .01 and P = .004, respectively), whereas Cx36 protein expression was significantly decreased after only 1 week (P = .01). CONCLUSIONS: That both retinal GJD2 mRNA and Cx36 protein expression levels were decreased after induction of myopia with negative lenses points to retinal circuits involving Cx36 in myopia development in the guinea pig. Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Association between Gestational Age, Birth Weight, Parental Age at Childbirth, Mode of Delivery, and Infantile Esotropia / Junting Huang in OVS : Optometry & Vision Science, vol. 99, 11 (Novembre 2022)
[article]
in OVS : Optometry & Vision Science > vol. 99, 11 (Novembre 2022)
Titre : Association between Gestational Age, Birth Weight, Parental Age at Childbirth, Mode of Delivery, and Infantile Esotropia Type de document : article de périodique Auteurs : Junting Huang ; Qianwen Zheng ; Kailai Nie ; Hong Wei ; Longqian Liu Année de publication : 2022 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:E:Ésotropie:Ésotropie / étiologie
[Thésaurus Mesh]:E:Ésotropie:Ésotropie / prévention et contrôle
[Thésaurus Mesh]Appréciation des risques
[Thésaurus Mesh]Chine
[Thésaurus Mesh]Collecte de données
[Thésaurus Mesh]Enfant
[Thésaurus Mesh]ÉsotropieRésumé : SIGNIFICANCE: This study investigated the potential perinatal risk factors associated with infantile esotropia in a Chinese population, including advanced parental age at childbirth and mode of delivery. The findings may be significant in developing better intervention strategies for infantile esotropia. PURPOSE: This study aimed to investigate the associations between gestational age, birth weight, parental age at childbirth, mode of delivery, family history of strabismus, and infantile esotropia in the Chinese population. METHODS: Ninety-nine patients with infantile esotropia and 117 control subjects were enrolled between March 2018 and March 2021. Detailed questionnaires were administered to parents to collect relevant information. Univariate and multivariate logistic regression models were used to identify possible risk factors of infantile esotropia. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire