Résumé : | Topical Review: Studies of Ocular Function and Disease Using
Hyperspectral Imaging
James M. Beach, PhD,1 Madeeha Rizvi, BS,1 Caitlin B. Lichtenfels, BS,1 Robert Vince, PhD,1 and Swati S. More, PhD1
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SIGNIFICANCE: Advances in imaging technology over the last two decades have produced significant innovations
in medical imaging. Hyperspectral imaging (HSI) is one of these innovations, enabling powerful new imaging tools
for clinical use and greater understanding of tissue optical properties and mechanisms underlying eye disease.
Hyperspectral imaging is an important and rapidly growing area in medical imaging, making possible the concurrent collection of spectroscopic and spatial information that is usually obtained from separate optical recordings. In
this review, we describe several mainstream techniques used in HSI, along with noteworthy advances in optical
technology that enabled modern HSI techniques. Presented also are recent applications of HSI for basic and applied eye research, which include a novel method for assessing dry eye syndrome, clinical slit-lamp examination of
corneal injury, measurement of blood oxygen saturation in retinal disease, molecular changes in macular degeneration, and detection of early stages of Alzheimer disease. The review also highlights work resulting from integration
of HSI with other imaging tools such as optical coherence tomography and autofluorescence microscopy and discusses the adaptation of HSI for clinical work where eye motion is present. Here, we present the background and
main findings from each of these reports along with specific references for additional details. |