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Pilocarpine
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
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Approche pharmacologique de la presbytie [partie I] / Jean-Pierre Lagacé in L'optométriste (UNIQUEMENT ACCESSIBLE EN PDF), vol. 44, 03 (Mai-juin 2022)
[article]
in L'optométriste (UNIQUEMENT ACCESSIBLE EN PDF) > vol. 44, 03 (Mai-juin 2022)
Titre : Approche pharmacologique de la presbytie [partie I] Type de document : article de périodique Auteurs : Jean-Pierre Lagacé Année de publication : 2022 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:P:Presbytie:Presbytie / thérapie
[Thésaurus Mesh]:P:Presbytie:Presbytie / traitement médicamenteux
[Thésaurus Mesh]Phentolamine
[Thésaurus Mesh]Pilocarpine
[Thésaurus Mesh]Presbytie
[Thésaurus Mesh]Solutions ophtalmiques
[Thésaurus Mesh]Troubles de la visionRésumé : Dans le monde, on compte 1,8 milliard de presbytes, dont 826 millions sont malvoyants en raison d’une correction visuelle inadéquate. Bien que la plupart des Américains aient accès à une correction de la vision de près, nombre d’entre eux ne sont pas satisfaits de leur expérience de la presbytie ou des possibilités de la corriger. Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Effect of Topical Pilocarpine on Choroidal Thickness in Healthy Subjects / Dmitrii S Maltsev in OVS : Optometry & Vision Science, vol. 97, 06 (Juin 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 06 (Juin 2020) . - p. 457-461
Titre : Effect of Topical Pilocarpine on Choroidal Thickness in Healthy Subjects Type de document : article de périodique Auteurs : Dmitrii S Maltsev ; Alexei N Kulikov ; Alexander S. Vasiliev Année de publication : 2020 Article en page(s) : p. 457-461 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Collecte de données
[Thésaurus Mesh]Pilocarpine
[Thésaurus HELB]:Optique:Épaisseur choroïdienne fovéolaireRésumé : SIGNIFICANCE: This is a proof-of-concept study showing the possibility of pharmacological control for choroidal thickness using pilocarpine as an agent that causes 2 to 5% choroidal thinning in healthy eyes after the instillation. PURPOSE: The purpose of this article was to study the effect of instillation of 1% pilocarpine on choroidal thickness in healthy subjects. METHODS: Sixteen healthy individuals (seven males and nine females; mean ± standard deviation age, 25.8 ± 3.3 years) were included. All participants received optical coherence tomography to evaluate subfoveal choroidal thickness (SCT) and choroidal area on cross-sectional scan within 4-mm central area. Axial length was measured using optical biometry. Optical coherence tomography was performed before and after pilocarpine was instilled six times for a 75-minute period in one eye; the fellow eye was used as the control. Subfoveal choroidal thickness and choroidal area were measured by two masked graders in random fashion and averaged for analysis. RESULTS: After instillation of 1% pilocarpine, percentage SCT change in study and control eye was −3.3 ± 3.8% and 0.4 ± 3.2%, respectively (P = .03). Percentage change choroidal area in study and control eye was −2.3 ± 2.5% and 0.8 ± 3.3%, respectively (P < .001). There was a correlation between percentage SCT change and axial length (r = −0.56, P < .001), as well as between percentage SCT change and baseline SCT (r = 0.72, P < .001). CONCLUSIONS: Instillation of 1% pilocarpine causes a decrease of choroidal thickness, which is more substantial in eyes with short axial length and thick choroid. Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Topical Review: Pilocarpine-induced Miosis as Help for Early Presbyopes? / Gerald Westheimer in OVS : Optometry & Vision Science, vol. 99, 08 (Aout 2022)
[article]
in OVS : Optometry & Vision Science > vol. 99, 08 (Aout 2022)
Titre : Topical Review: Pilocarpine-induced Miosis as Help for Early Presbyopes? Type de document : article de périodique Auteurs : Gerald Westheimer Année de publication : 2022 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:A:Acuité visuelle:Acuité visuelle / effets des médicaments et des substances chimiques
[Thésaurus Mesh]:P:Presbytie:Presbytie / thérapie
[Thésaurus Mesh]Pilocarpine
[Thésaurus Mesh]Presbytie
[Thésaurus HELB]:Optique:solution ophtalmiqueRésumé : SIGNIFICANCE: The clinical utility of ophthalmic pilocarpine-induced pupil constriction to help overcome image blur of close-up targets in patients with failing accommodation is examined. Pilocarpine in low-concentration ophthalmic solution eye drops constricts the pupil to approximately 2 mm and thus reduces defocus blur. To gain regulatory approval of this drug for the treatment of presbyopia, clinical trials were conducted with 1.25% pilocarpine. Near vision was improved in a modest proportion of early presbyopes: between 12 and 22% more patients reached criterion near visual acuity than with a placebo, depending on conditions. The drug is well tolerated, and its effect has onset of only minutes and lasts several hours. Small pupils will cause diminished night vision and may have an impact on distance acuity to which possible minor drug-induced accommodative spasms could contribute. The therapy has a role for patients who want to postpone or briefly pause dioptric supplementation of their failing accommodation. No convincing case has been made for one version of ophthalmic pilocarpine over another. Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire