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Descripteurs (mots clés)
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Smog / analyse | Smog / effets indésirables | Smog / prévention et contrôle |
Smog
A mixture of smoke and fog polluting the atmosphere. (Dorland, 27th ed)
Synonyme(s)
Brouillard de fumée; Brouillard de pollutionRelation(s)
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Methylation analysis for multiple gene promoters in non-small cell lung cancers in high indoor air pollution region in China / Xinwei Huang in Bulletin du cancer, vol. 105, 9 (Septembre 2018)
[article]
in Bulletin du cancer > vol. 105, 9 (Septembre 2018) . - p. 746-754
Titre : Methylation analysis for multiple gene promoters in non-small cell lung cancers in high indoor air pollution region in China Type de document : article de périodique Auteurs : Xinwei Huang ; Chaoqun Wu ; Yu Fu ; [et al.] Année de publication : 2018 Article en page(s) : p. 746-754 Note générale : Doi : 10.1016/j.bulcan.2018.05.004 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:T:Tumeurs du poumon:Tumeurs du poumon / diagnostic
[Thésaurus Mesh]Chine
[Thésaurus Mesh]Exposition environnementale
[Thésaurus Mesh]Méthylation de l'ADN
[Thésaurus Mesh]Pollution de l'air
[Thésaurus Mesh]Pollution de l'environnement
[Thésaurus Mesh]Smog
[Thésaurus Mesh]Tumeurs du poumonMots-clés : Pollution de l'air Smog Tumeurs du poumon Exposition environnementale Chine Méthylation de l'ADN Résumé : Aim
The prevalence and mortality rates of lung cancer in Xuanwei, Yunnan, China, are the highest in the world. The severe indoor air pollution caused by smoky coals with high benzo (a)pyrene (BaP) and quartz levels is the main environmental factor. The aim of this study was to investigate methylation profiles of promoters in eight genes in primary non-small cell lung cancers (NSCLC) exposed to smoky coals.
Materials and methods
Candidate genes including CDKN2A, DLEC1, CDH1, DAPK, RUNX3, APC, WIF1 and MGMT were determined for the promoter methylation status using Nested methylation-specific PCR (nMSP) in primary 23NSCLC tissues and in circulating tumor DNA (ctDNA) isolated from 42plasma samples (9matched to tissues) as well as 10healthy plasma samples, using Sanger sequencing to verify the results.
Results
Seven of the 8genes, except MGMT, had relatively high methylation frequencies ranging from 39%–74% in tissues. Moreover, methylation frequencies in five genes identified in lung cancer plasma were 45% for CDKN2A, 48% for DLEC1, 76% for CDH1, 14% for DAPK, 29% for RUNX3, with a relatively good concordance of methylation among 9 tissues and paired plasma. However, the genes from all healthy plasma showed no methylation.
Conclusions
A panel of genes including CDKN2A, DLEC1, CDH1, DAPK and RUNX3 may be used as potential epigenetic biomarkers for early lung cancer detection. CDH1 promoter methylation was associated with lung cancer metastasis in areas of air pollution from buring of smoky coals. DLEC1 and CDH1 exhibited specific high methylation frequencies, different from previous reports.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité B Périodique Erasme - périodiques Périodiques Disponible