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Etiology of onychomycosis in patients in turkey / Fatma Pelin Cengiz in Journal of the American Podiatric Medical Association, vol. 108, 3 (Mai - juin 2018)
[article]
in Journal of the American Podiatric Medical Association > vol. 108, 3 (Mai - juin 2018) . - p. 253-256
Titre : Etiology of onychomycosis in patients in turkey Type de document : article de périodique Auteurs : Fatma Pelin Cengiz ; [et al.] Année de publication : 2018 Article en page(s) : p. 253-256 Langues : Anglais (eng) Descripteurs (mots clés) : [Thésaurus Mesh]:O:Onychomycose:Onychomycose / étiologie
[Thésaurus Mesh]Onychomycose
[Thésaurus Mesh]PiedMots-clés : Onychomycosis etiology foot Résumé : Background: Onychomycosis is a chronic nail infection caused by dermatophytes, Candida, nondermatophyte molds, and Trichosporon. The purpose of this study was to identify the underlying pathogen in patients with onychomycosis in our region. Methods: A retrospective analysis of 225 cases with onychomycosis, diagnosed over a 27-month period at the Department of Dermatoveneorology, Bezmialem Vakif University, Istanbul, Turkey, and confirmed with culture, was performed. Results: Patient age ranged from 2 to 87 years (mean 6 SD, 41.59 6 17.61), and female patients were more commonly affected (120 cases, 53.3%) than male patients. Lateral and distal subungual onychomycosis was detected in 180 cases (80%). Etiologic agents were as follows: Trichophyton rubrum, 77 cases (34.2%); Trichophyton mentagrophytes, 30 cases (13.3%), Candida albicans, 28 cases (12.4%); Candida parapsilosis, 25 cases (11.1%); Acremonium species, one case (0.4%); Aspergillus species, two cases (0.9%); Fusarium species, four cases (1.3%); and Trichosporon species, three cases (1.3%). Conclusions: The most frequent isolated etiologic agents were T rubrum for toenails and C albicans for fingernails. Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité J Périodique Erasme - périodiques Périodiques Disponible Onychomycosis infections : do polymerase chain reaction and culture reports agree? / Aditya K. Gupta in Journal of the American Podiatric Medical Association, vol. 107, 4 (Juillet- août 2017)
[article]
in Journal of the American Podiatric Medical Association > vol. 107, 4 (Juillet- août 2017) . - p. 280-286
Titre : Onychomycosis infections : do polymerase chain reaction and culture reports agree? Type de document : article de périodique Auteurs : Aditya K. Gupta, Auteur ; [et al.], Auteur Année de publication : 2017 Article en page(s) : p. 280-286 Langues : Anglais (eng) Descripteurs (mots clés) : [Thésaurus Mesh]:O:Onychomycose:Onychomycose / étiologie
[Thésaurus Mesh]Onychomycose
[Thésaurus Mesh]Réaction de polymérisation en chaîne
[Thésaurus Mesh]Techniques de typage mycologique
[Thésaurus HELB]:Paramédical:Culture mycologiqueMots-clés : onychomycosis etiology mycological typing techniques Mycological culture polymerase chain reaction Résumé : Background: Mycological culture is the traditional method for identifying infecting agents of onychomycosis despite high false-negative results, slower processing, and complications surrounding nondermatophyte mold (NDM) infections. Molecular polymerase chain reaction (PCR) methods are faster and suited for ascertaining NDM infections.
Methods: To measure agreement between culture and PCR methods for identification of infecting species of suspected onychomycosis, single toenail samples from 167 patients and repeated serial samples from 43 patients with suspected onychomycosis were processed by culture and PCR for identification of 16 dermatophytes and five NDMs. Agreement between methods was quantified using the kappa statistic (j).
Results: The methods exhibited fair agreement for the identification of all infecting organisms (single samples: j ¼ 0.32; repeated samples: j ¼ 0.38). For dermatophytes, agreement was moderate (single samples: j ¼ 0.44; repeated samples: j ¼ 0.42). For NDMs, agreement was poor with single samples (j¼0.16) but fair with repeated samples (j ¼0.25). Excluding false-negative reports from analyses improved agreement between methods in all cases except the identification of NDMs from single samples.
Conclusions: Culture was three or four times more likely to report a false-negative result compared with PCR. The increased agreement between methods observed by excluding false-negative reports statistically clarifies and highlights the major discord caused by false-negative cultures. The increased agreement of NDM identification from poor to fair with repeated sampling along with their poor agreement in the single samples, with and without false-negatives, affirms the complications of NDM identification and supports the recommendation that serial samples help confirm the diagnosis of NDM infections.
Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité J Périodique Erasme - périodiques Périodiques Disponible Trichophyton rubrum DNA Strains in Patients with Onychomycosis with Persistent Mixed Infections Involving a Nondermatophyte Mold / Aditya K. Gupta in Journal of the American Podiatric Medical Association, vol. 110, 06 (Novembre-décembre 2020)
[article]
in Journal of the American Podiatric Medical Association > vol. 110, 06 (Novembre-décembre 2020)
Titre : Trichophyton rubrum DNA Strains in Patients with Onychomycosis with Persistent Mixed Infections Involving a Nondermatophyte Mold Type de document : article de périodique Auteurs : Aditya K. Gupta ; Kerry-Ann Nakrieko Année de publication : 2020 Langues : Anglais (eng) Descripteurs (mots clés) : [Thésaurus Mesh]:O:Onychomycose:Onychomycose / étiologie
[Thésaurus Mesh]Antifongiques
[Thésaurus Mesh]OnychomycoseRésumé : Background
Onychomycosis is estimated to occur in approximately 10% of the global population, with most cases caused by Trichophyton rubrum. Some persistent onychomycosis is caused by mixed infections of T rubrum and one or more co-infecting nondermatophyte molds (NDMs). In onychomycosis, T rubrum strain types may naturally switch and may also be triggered to switch in response to antifungal therapy. T rubrum strain types in mixed infections of onychomycosis have not been characterized.
Methods
T rubrum DNA strains in mixed infections of onychomycosis containing co-infecting NDMs were compared with a baseline North American population through polymerase chain reaction amplification of ribosomal DNA tandemly repetitive subelements (TRSs) 1 and 2. The baseline DNA strain types were determined from 102 clinical isolates of T rubrum. The T rubrum DNA strain types from mixed infections were determined from 63 repeated toenail samples from 15 patients.
Results
Two unique TRS-2 types among the clinical isolates contributed to four unique TRS-1 and TRS-2 strain types. Six TRS-1 and TRS-2 strain types represented 92% of the clinical isolates of T rubrum. Four TRS-1 and TRS-2 strain types accounted for 100% of the T rubrum within mixed infections.
Conclusions
Four unique North American T rubrum strains were identified. In support of a shared ancestry, the T rubrum DNA strain types found in mixed infections with NDMs were among the most abundant types. A population of T rubrum strains in mixed infections of onychomycosis has been characterized, with more than one strain detected in some nails. The presence of a co-infecting NDM in mixed infections may contribute to failed therapy by stabilizing the T rubrum strain type, possibly preventing the antifungal therapy–induced strain type switching observed with infections caused by T rubrum alone.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
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