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Descripteurs (mots clés)
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Infections virales de l'oeil
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
Synonyme(s)
Infections virales des yeux; Infections virales ophtalmiques; Viroses oculairesRelation(s)
- voir aussi au terme générique : [Descripteurs (mots clés)] Maladies virales
- voir aussi au terme générique : [Descripteurs (mots clés)] Infections de l'oeil
- voir aussi au terme spécifique : [Descripteurs (mots clés)] Conjonctivite virale
- voir aussi au terme spécifique : [Descripteurs (mots clés)] Zona ophtalmique
- voir aussi au terme spécifique : [Descripteurs (mots clés)] Kératite herpétique
- voir aussi au terme spécifique : [Descripteurs (mots clés)] Rétinite à cytomégalovirus
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Correlation of Adenoviral Titers with Severity of Adenoviral Conjunctivitis and Time to Viral Clearance for 21 Days / Christina E Morettin in OVS : Optometry & Vision Science, vol. 100, 03 (Mars 2023)
[article]
in OVS : Optometry & Vision Science > vol. 100, 03 (Mars 2023)
Titre : Correlation of Adenoviral Titers with Severity of Adenoviral Conjunctivitis and Time to Viral Clearance for 21 Days Type de document : article de périodique Auteurs : Christina E Morettin ; Jennifer S. Harthan ; Julia B. Huecker ; Chamila D. Perera ; Tammy P. Than ; Meredith M. Whiteside ; Spencer D. Johnson ; Ellen Shorter ; Mary K. Migneco ; Christian K. Olson ; Christopher S. Alferez ; Devon Camp ; Andrew Hartwick ; Mae O. Gordon Année de publication : 2023 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Conjonctivite
[Thésaurus Mesh]Infections virales de l'oeil
[Thésaurus Mesh]Signes et symptômesMots-clés : conjonctivite adénovirale Résumé : SIGNIFICANCE: This investigation reports the correlation of conjunctival viral titers in adenoviral conjunctivitis with patient-reported symptoms and clinician-graded signs for 21 days of follow-up. PURPOSE: Adenoviral conjunctivitis is a highly contagious viral eye infection with significant morbidity and economic impact. This study investigates whether severity of signs and symptoms and time to viral clearance are correlated with conjunctival viral titers at baseline and during 21 days of follow-up. METHODS: The Reducing Adenoviral Patient Infected Days study was a pilot study of the efficacy of a single in-office administration of ophthalmic 5% povidone-iodine. This article outlines longitudinal analyses after the primary outcome report. Of 212 participants screened, 28 participants with quantitative polymerase chain reaction–confirmed adenoviral conjunctivitis were randomized and had follow-up visits on days 1, 2, 4, 7, 14, and 21. At each visit, clinician-graded signs, participant-reported symptoms, and a conjunctival swab for quantitative polymerase chain reaction analysis were obtained. The correlation of viral titers with symptoms and signs was calculated: (1) cross-sectionally at each visit and (2) longitudinally for 21 days using a repeated-measures mixed-effects model. RESULTS: Twenty-five of 28 participants had sufficient data for this report. Higher viral titers for 21 days were correlated with greater severity of symptoms (tearing, matting, and redness, r ≥ 0.70; P < .02) and greater severity of clinical signs (bulbar redness and serous discharge, r ≥ 0.60; P < .01). Eyes with highest baseline viral titers required longer time to viral clearance (r = 0.59, P = .008). Signs and symptoms persisted in approximately half of the eyes even after viral clearance. CONCLUSIONS: Higher conjunctival viral titers across 21 days were strongly correlated with more severe signs and symptoms and longer time to viral clearance. Our results also indicate that symptoms and signs can persist after viral clearance. Optom Vis Sci 20 Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
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