Résumé : | To compare physical function, pain, impairments (stiffness, range of motion, and strength), and health-related quality of life (HRQoL) outcomes between patients with and without diabetes mellitus, before and after a total knee arthroplasty (TKA).
Design
Prognosis systematic review.
Literature Search
We searched MEDLINE/PubMed, CINAHL, SPORTDiscus, and Web of Science to August 2019.
Study Selection Criteria
We included longitudinal studies that examined physical function, pain, impairments, and HRQoL outcomes among patients receiving a TKA and with or without diabetes.
Data Synthesis
For quantitative synthesis, we stratified outcomes based on time relative to TKA: preoperative, less than 1 year after a TKA (early postoperative), and 1 year or more after a TKA (late postoperative). We used random-effects meta-analysis to calculate standardized mean differences (SMDs) and 95% confidence intervals (CIs). We used the Grading of Recommendations Assessment, Development and Evaluation system for qualitative synthesis.
Results
We included 21 studies (n = 17 472 patients). Patients with diabetes mellitus had worse preoperative physical function (SMD, −0.16; 95% CI: −0.24, −0.08) and HRQoL (SMD, −0.16; 95% CI: −0.26, −0.05), worse early postoperative pain (SMD, −0.22; 95% CI: −0.39, −0.05) and strength (SMD, −0.45; 95% CI: −0.77, −0.14), and worse late postoperative physical function (SMD, −0.23; 95% CI: −0.40, −0.06), range of motion (SMD, −0.23; 95% CI: −0.46, 0.00), and HRQoL (SMD, −0.19; 95% CI: −0.29, −0.08) than patients without diabetes mellitus. The overall risk of bias across studies was high, and the certainty of evidence ranged from low to very low.
Conclusion
Patients with diabetes mellitus had worse patient-reported and clinician-assessed outcomes before and after a TKA. Given the limitations of included studies, these results may change with future research. |