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Auteur Anbin Hu
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Ajouter le résultat dans votre panier Affiner la rechercheBlocking Tim-3 or/and PD-1 reverses dysfunction of tumor-infiltrating lymphocytes in HBV-related hepatocellular carcinoma / Furong Liu in Bulletin du cancer, vol. 105, 5 (Mai 2018)
[article]
in Bulletin du cancer > vol. 105, 5 (Mai 2018) . - p. 493-501
Titre : Blocking Tim-3 or/and PD-1 reverses dysfunction of tumor-infiltrating lymphocytes in HBV-related hepatocellular carcinoma Type de document : article de périodique Auteurs : Furong Liu ; Gucheng Zeng ; Anbin Hu ; [et al.] Année de publication : 2018 Article en page(s) : p. 493-501 Note générale : https://doi.org/10.1016/j.bulcan.2018.01.018 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Carcinome hépatocellulaire
[Thésaurus Mesh]Immunothérapie adoptive
[Thésaurus Mesh]Lymphocytes TIL
[Thésaurus Mesh]Récepteur-1 de mort cellulaire programmée
[Thésaurus Mesh]Virus de l'hépatite BMots-clés : Immunothérapie adoptive Carcinome hépatocellulaire Virus de l'hépatite B Lymphocytes TIL Récepteur-1 de mort cellulaire programmée Protéine HAVCR2, humain TIM3 T cell Ig- and mucin- domain-containing molecule-3 PD-1 HBV-HCC carcinome hépatocellulaire associé au virus de l'hépatite B Résumé : Background
The immunosuppression of tumor-infiltrating lymphocytes (TILs) is associated with rapid progression of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). T cell Ig- and mucin-domain-containing molecule-3 (Tim-3) and programmed cell death 1 (PD-1) are important inhibitory molecules expressed on the surface of T cells, but their roles in the function of TILs in HBV-HCC are poorly understood. We aimed to study the roles of these two markers in HBV-HCC.
Methods
Ninety patients with pathologically confirmed HBV-associated HCC were enrolled in our study. Blood samples, paired fresh tumor tissues and adjacent tissues were collected, and isolating peripheral blood mononuclear cells, TILs and adjacent-infiltrating lymphocytes were isolated from these samples. The patients were followed-up to allow survival analysis.
Results
Tim-3 or/and PD-1 was up-regulated expressed on CD4+ and CD8+ TILs in HBV-HCC patients and a higher proportion of TILs expressed PD-1 alone. Tim-3+ and PD-1+ TILs greatly decreased secretion of IFN-? and TNF-a. Expression of Tim-3 and PD-1 on TILs negatively correlated with disease-free survival of HCC patients. Direct blockade of Tim-3 and PD-1 in vitro significantly enhanced TILs proliferation and secretion of IFN-? and TNF-a.
Conclusion
Expression of Tim-3 and/or PD-1 on TILs impairs their function and correlates negatively with disease-free survival in HBV-HCC. Direct blockade of Tim-3 and PD-1 restores anti-tumor effects of TILs, which suggests a potential target for novel immunotherapy in HBV-HCC.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité B Périodique Erasme - périodiques Périodiques Disponible