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Auteur Dimitra Skondra
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Ajouter le résultat dans votre panier Affiner la rechercheCase Report: Peripheral Retinal Ischemia and Retinal Neovascularization in von Willebrand Disease / Steven Charles Quan in OVS : Optometry & Vision Science, vol. 98, 04 (Avril 2021)
[article]
in OVS : Optometry & Vision Science > vol. 98, 04 (Avril 2021)
Titre : Case Report: Peripheral Retinal Ischemia and Retinal Neovascularization in von Willebrand Disease Type de document : article de périodique Auteurs : Steven Charles Quan ; Dimitra Skondra Année de publication : 2021 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Diagnostic
[Thésaurus Mesh]Maladies de von Willebrand
[Thésaurus Mesh]Néovascularisation rétinienne
[Thésaurus Mesh]Occlusion artérielle rétinienneRésumé : IGNIFICANCE
Although von Willebrand disease is the most common inherited bleeding disorder, there are only a few published reports of ocular complications. To our knowledge, this is the first case of peripheral retinal ischemia and retinal neovascularization in a patient with von Willebrand disease.
PURPOSE
This study aimed to demonstrate the value of multispecialty care when exploring a diagnosis for bilateral retinopathy.
CASE REPORT
A 55-year-old African American woman presented with peripheral retinal hemorrhages on routine examination. She was asymptomatic and did not have any personal or family history of bleeding disorders. Blood work was ordered, and she was referred to a retinal specialist who found peripheral telangiectasia, retinal ischemia, and leakage on fluorescein angiography, consistent with retinal neovascularization. Laser photocoagulation was performed while numerous specialists were consulted to determine the cause for her retinopathy. Laboratory testing confirmed low-grade type 1 von Willebrand disease. She was monitored without systemic treatment. She remained stable and asymptomatic, but her retinal neovascularization did not regress fully, so laser treatment was repeated.
CONCLUSIONS
This case described a new finding of peripheral retinal ischemia and retinal neovascularization in von Willebrand disease. It was discovered in an asymptomatic patient who did not have a history of bleeding but presented with bilateral retinal hemorrhages. Diagnosis was challenging because of the high degree of variation in this bleeding disorder, requiring extensive testing and careful consideration of the individual's clinical profile. Most people with von Willebrand disease do not know they have the disease because symptoms are mild or absent, so most cases are unreported. The von Willebrand factor is poorly recognized in ocular disease, but given its role in angiogenesis, it may be a valuable target to consider in future research.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Case report: varicella-zoster encephalitis with acute retinal necrosis and oculomotor nerve palsy / Steven Charles Quan in OVS : Optometry & Vision Science, vol. 96, 05 (Mai 2019)
[article]
in OVS : Optometry & Vision Science > vol. 96, 05 (Mai 2019)
Titre : Case report: varicella-zoster encephalitis with acute retinal necrosis and oculomotor nerve palsy Type de document : article de périodique Auteurs : Steven Charles Quan ; Dimitra Skondra Année de publication : 2019 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus HELB]:Optique:Perte de vision
[Thésaurus HELB]:Paramédical:Prévention
[Thésaurus Mesh]:E:Encéphalite zostérienne:Encéphalite zostérienne / complications
[Thésaurus Mesh]:S:Syndrome de nécrose rétinienne aigüe:Syndrome de nécrose rétinienne aigüe / thérapie
[Thésaurus Mesh]Syndrome de nécrose rétinienne aigüeRésumé : SIGNIFICANCE Varicella-zoster virus is a common cause of morbidity and vision loss in patients worldwide. It can affect any structure of the eye, from keratitis to acute retinal necrosis. Rapid diagnosis and treatment significantly improve clinical outcomes and quality of life.
PURPOSE The purpose of this study was to demonstrate a case where urgent referral to the emergency department was required to treat a patient with disseminated herpes zoster infection.
CASE REPORT This is a rare case of varicella-zoster virus encephalitis in a 70-year-old immunocompetent white man who initially presented to the eye clinic for vertical diplopia and floaters. He also had prior thoracic dermatomal rash, followed by new-onset headaches and cerebellar ataxia. Examination revealed a partial oculomotor nerve palsy in the right eye with bilateral optic disc edema and areas of retinitis consistent with acute retinal necrosis in both eyes. Polymerase chain reaction analysis of his aqueous humor and cerebrospinal fluid confirmed an active zoster infection. He received combination systemic and intravitreal antiviral medication until his retinitis resolved but required adjustments for recalcitrant disease and drug-induced nephrotoxicity. While on maintenance dosing of oral valacyclovir, he experienced reactivation in the form of bilateral vasculitis, which was successfully managed once restarting therapeutic oral dosing.
CONCLUSIONS This case describes a successful clinical course of acute retinal necrosis with strategies for its treatment in the setting of varicella-zoster encephalitis. Antiviral medication should be given as soon as possible, as prompt treatment has been shown to improve patient outcomes, although prognosis is typically poor in these cases. Multiple specialists are often needed to address different clinical challenges, including central nervous system involvement, viral strain resistance, disease reactivation, and drug toxicity.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire