Titre : | Periungual Amelanocytic Malignant Melanoma with Osteocartilaginous Differentiation of the Right Hallux |
Type de document : | article de périodique |
Auteurs : | Enzo Leone ; Gene Mirkin ; Xingpei Hao |
Année de publication : | 2023 |
Langues : | Anglais (eng) |
Descripteurs (mots clés) : | [Thésaurus HELB]:Paramédical:Chirurgie [Thésaurus Mesh]Hallux [Thésaurus Mesh]Mélanocytes [Thésaurus Mesh]Mélanome [Thésaurus Mesh]Ongle incarné
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Mots-clés : | mélanome malin à différenciation ostéocartilagineuse |
Résumé : | Malignant melanoma with osteocartilaginous differentiation is extremely rare. We report a case of periungual osteocartilaginous melanoma (OCM) on the right hallux. A 59-year-old man presented with a rapidly growing mass with drainage on his right great toe after treatment of ingrown toenail and infection 3 months earlier. Physical examination showed a 2.0 1.5 1.0-cm, malodorous, erythematous, dusky, granuloma-like mass along the fibular border of the right hallux. Pathologic evaluation of the excisional biopsy revealed diffuse epithelioid and chondroblastoma-like melanocytes with atypia and pleomorphism in the dermis with strong SOX10 immunostaining. The lesion was diagnosed as osteocartilaginous melanoma. The patient was referred to a surgical oncologist for further treatment. Osteocartilaginous melanoma is a rare variant of malignant melanoma that needs to be differentiated from chondroblastoma and other lesions. Immunostains for SOX10, H3K36M, and SATB2 are helpful for the differential diagnosis. |
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