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Éthambutol
An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
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Case Report: Long-term Structural and Functional Effects of Ethambutol Optic Neuropathy / Laura K. Addy in OVS : Optometry & Vision Science, vol. 97, 08 (Aout 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 08 (Aout 2020)
Titre : Case Report: Long-term Structural and Functional Effects of Ethambutol Optic Neuropathy Type de document : article de périodique Auteurs : Laura K. Addy ; Wendy W. Harrison Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Acuité visuelle
[Thésaurus Mesh]Champs visuels
[Thésaurus Mesh]Effets secondaires indésirables des médicaments
[Thésaurus Mesh]Éthambutol
[Thésaurus Mesh]Maladies du système nerveux
[Thésaurus Mesh]Oeil
[Thésaurus Mesh]Rétine
[Thésaurus Type de publication]Présentations de casMots-clés : réduction de l'épaisseur de la couche de fibres nerveuses de la rétine (RNFL) Résumé : SIGNIFICANCE: This case report demonstrates reduction in the retinal nerve fiber layer (RNFL) thickness and an
abnormal electroretinogram after toxic optic neuropathy from ethambutol, more than 1 year after improvements in
visual acuity (VA) and visual fields (VFs) were seen. Although many studies have described complications of ethambutol, continuing reduction in RNFL thickness 2 years after discontinuation has not been described elsewhere.
PURPOSE: It is well known that ethambutol can cause optic nerve toxicity, visual impairment, and VF loss. Visual
acuity can be regained after stopping the drug; however, the amount and time frame are variable. There are few
data on long-term follow-up of these cases to direct clinicians how to proceed once VA has stabilized. Here we present a case with 2 years of follow-up for a patient with ethambutol toxicity, showing the condition change even after
VA becomes normal.
CASE REPORT: A 61-year-old man presented shortly after discontinuing ethambutol for Mycobacterium avium
complex. Visual acuity values were 20/70 in the right eye and 20/125 in the left eye with cecocentral VF scotomas.
Optical coherence tomography showed normal RNFL. Visual-evoked potentials were significantly reduced and delayed. Over the course of 2 years, the patient became asymptomatic as VA and VF returned to normal and
visual-evoked potential improved. However, the optical coherence tomography RNFL was reduced from each visit
to the next, and the electroretinogram showed decreased scotopic and photopic amplitudes.
CONCLUSIONS: Signs of ethambutol toxicity may remain or worsen years after discontinuation, even in the absence of patient symptoms and with normal VA and VFPermalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
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