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Case Report: Acute Retinal Necrosis after Intravitreal Ranibizumab for Exudative Macular Degeneration / Ying Pan in OVS : Optometry & Vision Science, vol. 98, 03 (Mars 2021)
[article]
in OVS : Optometry & Vision Science > vol. 98, 03 (Mars 2021)
Titre : Case Report: Acute Retinal Necrosis after Intravitreal Ranibizumab for Exudative Macular Degeneration Type de document : article de périodique Auteurs : Ying Pan ; Xiaoli Huang ; Zhifeng Wu ; Shui Lu ; Tiantian Chen ; Wenjun Zou Année de publication : 2021 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:S:Syndrome de nécrose rétinienne aigüe:Syndrome de nécrose rétinienne aigüe / étiologie
[Thésaurus Mesh]Atteintes du nerf optique
[Thésaurus Mesh]Dégénérescence maculaire
[Thésaurus Mesh]Effets secondaires indésirables des médicaments
[Thésaurus Mesh]Syndrome de nécrose rétinienne aigüeMots-clés : ranibizumab traitement antiviral Résumé : SIGNIFICANCE: Acute retinal necrosis (ARN) may occur after intravitreal ranibizumab (IVR) treatment for patients
with exudative age-related macular degeneration (AMD). Awareness of this unusual but devastating complication
after IVR is needed. Early identification may help provide timely antiviral treatment and prevent irreversible visual loss.
PURPOSE: This study aimed to report a case of ARN after IVR in a patient with exudative AMD.
CASE REPORT: A 67-year-old male patient complained of blurred vision in his left eye for 1 month. The patient was
diagnosed with exudative AMD after detailed ophthalmic clinical evaluations. He received IVR once in his left eye.
Three days after IVR, he developed varicella-zoster virus–associated ARN, which was treated with systemic and intravitreal antiviral therapy. Because of progressive inflammation, the patient underwent 25G pars plana vitrectomy
with silicone oil tamponade. Seven months later, the patient was administered intravitreal aflibercept once in his
left eye. Three months after intravitreal aflibercept, he underwent removal of silicone oil, and retinal detachment
occurred 2 weeks after the surgery because of low IOP, and the patient eventually discontinued treatment.
CONCLUSIONS: This study reports the first case of varicella-zoster virus–associated ARN after IVR. Early ARN may
be very difficult to distinguish from intraocular inflammation after IVR. Therefore, early detection of viral DNA in
the intraocular fluid using polymerase chain reaction is recommended. Immediate antiviral treatment may be beneficial to prevent severe visual loss.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
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