A partir de cette page vous pouvez :
Retourner au premier écran avec les dernières notices... |
Détail de l'auteur
Auteur Marc Schulze
Documents disponibles écrits par cet auteur
Ajouter le résultat dans votre panier Affiner la rechercheBulbar Redness and Dry Eye Disease: Comparison of a Validated Subjective Grading Scale and an Objective Automated Method / Marc Schulze in OVS : Optometry & Vision Science, vol. 98, 02 (Février 2021)
[article]
in OVS : Optometry & Vision Science > vol. 98, 02 (Février 2021)
Titre : Bulbar Redness and Dry Eye Disease: Comparison of a Validated Subjective Grading Scale and an Objective Automated Method Type de document : article de périodique Auteurs : Marc Schulze ; Alison Ng ; Mike Yang ; Farah Panjwani ; Sruthi Srinivasan ; Lyndon Jones ; Michelle Senchyna Année de publication : 2021 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Étude comparative
[Thésaurus Mesh]Signes et symptômes
[Thésaurus Mesh]Syndromes de l'oeil secMots-clés : rougeur conjonctivale rougeur bulbaire Résumé : SIGNIFICANCE
In this study, assessments of conjunctival redness were performed to evaluate whether patients with or without dry eye disease (DED) could be discriminated based on this measure. Our findings suggest that subjectively grading redness by quadrant, as opposed to automated en face measurements, may be more suitable for this purpose.
PURPOSE
This study aimed to quantify bulbar redness using the validated bulbar redness (VBR) grading scale and an automated objective method (Oculus Keratograph 5M; K5M) in participants with DED and non-DED controls.
METHODS
Participants with DED (Ocular Surface Disease Index score ≥20 and Oxford scale corneal staining ≥2) and controls (Ocular Surface Disease Index score ≤10 and corneal staining ≤1) attended two study visits. In part 1A of visit 1, baseline bulbar redness was graded with the VBR scale in each conjunctival quadrant of both eyes, followed by automated measurements of temporal and nasal redness with the K5M. This was immediately followed by part 1B, during which a topical vasoconstrictor was instilled into both eyes. Redness assessments were repeated 5 and 30 minutes after instillation with both instruments. Participants returned 14 days later for visit 2, where the same assessments as for visit 1A were repeated.
RESULTS
Seventy-four participants (50 DED and 24 controls) completed the study. There were statistically significant differences in redness between the DED and control groups when assessed with the VBR scale (14/16 comparisons; all, P < .05), whereas no significant differences in K5M-derived redness between the DED and non-DED groups were found at any location or time point. Both subjective and objective instruments detected statistically significant reductions in redness 5 and 30 minutes after instillation of the vasoconstrictor (all, P < .01).
CONCLUSIONS
Although both subjective and objective instruments were sensitive to detecting changes in redness induced by vasoconstriction, statistically significant differences in redness between DED and control groups were only found using the VBR scale.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Lipid Analysis on Block Copolymer–containing Packaging Solution and Lens Care Regimens: A Randomized Clinical Trial / Amanda Shows in OVS : Optometry & Vision Science, vol. 97, 08 (Aout 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 08 (Aout 2020)
Titre : Lipid Analysis on Block Copolymer–containing Packaging Solution and Lens Care Regimens: A Randomized Clinical Trial Type de document : article de périodique Auteurs : Amanda Shows ; Wolfgang Sickenberger ; Jennifer S. Fogt ; Marc Schulze ; Christopher Lievens ; Loretta B. Szczotka-Flynn ; Stefan Schwarz ; Jessie M. Lemp-Hull Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Cholestérol
[Thésaurus Mesh]Études prospectives
[Thésaurus Mesh]Lentilles de contact
[Thésaurus Mesh]Solutions pour lentilles cornéennesMots-clés : Lentille silicone-hydrogel lentilles Lotrafilcon B Résumé : SIGNIFICANCE: Lotrafilcon B lenses packaged in and cared for with block copolymer–containing (polyoxyethylenepolyoxybutylene; EOBO) lens care solutions resulted in lower cholesterol extraction than each of the habitual silicone
hydrogel lens/multipurpose solution (MPS) regimens tested.
PURPOSE: This study aimed to compare the extracted cholesterol of lotrafilcon B lenses packaged in and cared for
with EOBO-containing lens care solutions with the extracted cholesterol of habitual silicone hydrogel lenses cared
for with MPS not containing EOBO.
METHODS: In this prospective, randomized, observer-masked parallel study, habitual wearers of senofilcon C,
senofilcon A, comfilcon A, and samfilcon A contact lenses using a non-EOBO MPS were randomized 1:1 to
lotrafilcon B lenses packaged in and cared for with EOBO-containing solutions or to their habitual lenses and
MPS. Subjects randomized to lotrafilcon B were further randomized to one of two EOBO-containing lens care solutions, OPTI-FREE PUREMOIST or CLEAR CARE PLUS with HydraGlyde (Alcon Laboratories, Inc., Fort Worth, TX).
A subset of right eye lenses was collected after wear, and total cholesterol was extracted and measured using a fluorometric enzymatic assay.
RESULTS: Of 143 lenses analyzed, 95 were from subjects randomized to their habitual lenses/MPS and 48 to
lotrafilcon B + EOBO lenses plus CLEAR CARE PLUS with HydraGlyde or OPTI-FREE PUREMOIST. The mean
amounts of cholesterol extracted from lotrafilcon B + EOBO lenses cared for with CLEAR CARE PLUS with
HydraGlyde (0.28 ± 0.18 μg/lens) and OPTI-FREE PUREMOIST (0.28 ± 0.48 μg/lens) were significantly lower
than those extracted from senofilcon C (4.18 ± 3.25 μg/lens), senofilcon A (2.19 ± 2.69 μg/lens), comfilcon A
(2.17 ± 1.47 μg/lens), and samfilcon A (2.07 ± 1.48 μg/lens) lenses used with MPS (P < .0001 each).
CONCLUSIONS: Cholesterol sorption was significantly lower in wearers of lotrafilcon B lenses cared for with
polyoxyethylene-polyoxybutylene–containing lens care solutions than in users of habitual silicone hydrogel lenses
cared for with non–polyoxyethylene-polyoxybutylene MPS.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire