A partir de cette page vous pouvez :
Retourner au premier écran avec les dernières notices... |
Détail de l'auteur
Auteur Sruthi Srinivasan
Documents disponibles écrits par cet auteur
Ajouter le résultat dans votre panier Affiner la rechercheBulbar Redness and Dry Eye Disease: Comparison of a Validated Subjective Grading Scale and an Objective Automated Method / Marc Schulze in OVS : Optometry & Vision Science, vol. 98, 02 (Février 2021)
[article]
in OVS : Optometry & Vision Science > vol. 98, 02 (Février 2021)
Titre : Bulbar Redness and Dry Eye Disease: Comparison of a Validated Subjective Grading Scale and an Objective Automated Method Type de document : article de périodique Auteurs : Marc Schulze ; Alison Ng ; Mike Yang ; Farah Panjwani ; Sruthi Srinivasan ; Lyndon Jones ; Michelle Senchyna Année de publication : 2021 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]Étude comparative
[Thésaurus Mesh]Signes et symptômes
[Thésaurus Mesh]Syndromes de l'oeil secMots-clés : rougeur conjonctivale rougeur bulbaire Résumé : SIGNIFICANCE
In this study, assessments of conjunctival redness were performed to evaluate whether patients with or without dry eye disease (DED) could be discriminated based on this measure. Our findings suggest that subjectively grading redness by quadrant, as opposed to automated en face measurements, may be more suitable for this purpose.
PURPOSE
This study aimed to quantify bulbar redness using the validated bulbar redness (VBR) grading scale and an automated objective method (Oculus Keratograph 5M; K5M) in participants with DED and non-DED controls.
METHODS
Participants with DED (Ocular Surface Disease Index score ≥20 and Oxford scale corneal staining ≥2) and controls (Ocular Surface Disease Index score ≤10 and corneal staining ≤1) attended two study visits. In part 1A of visit 1, baseline bulbar redness was graded with the VBR scale in each conjunctival quadrant of both eyes, followed by automated measurements of temporal and nasal redness with the K5M. This was immediately followed by part 1B, during which a topical vasoconstrictor was instilled into both eyes. Redness assessments were repeated 5 and 30 minutes after instillation with both instruments. Participants returned 14 days later for visit 2, where the same assessments as for visit 1A were repeated.
RESULTS
Seventy-four participants (50 DED and 24 controls) completed the study. There were statistically significant differences in redness between the DED and control groups when assessed with the VBR scale (14/16 comparisons; all, P < .05), whereas no significant differences in K5M-derived redness between the DED and non-DED groups were found at any location or time point. Both subjective and objective instruments detected statistically significant reductions in redness 5 and 30 minutes after instillation of the vasoconstrictor (all, P < .01).
CONCLUSIONS
Although both subjective and objective instruments were sensitive to detecting changes in redness induced by vasoconstriction, statistically significant differences in redness between DED and control groups were only found using the VBR scale.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Comparison of Two Thermal Pulsation Systems in the Treatment of Meibomian Gland Dysfunction: A Randomized, Multicenter Study / Gina Wesley in OVS : Optometry & Vision Science, vol. 99, 04 (Avril 2022)
[article]
in OVS : Optometry & Vision Science > vol. 99, 04 (Avril 2022)
Titre : Comparison of Two Thermal Pulsation Systems in the Treatment of Meibomian Gland Dysfunction: A Randomized, Multicenter Study Type de document : article de périodique Auteurs : Gina Wesley ; Katherine M. Bickle ; Johnathon Downing ; Bret Fisher ; Brennan Greene ; Colton Heinrich ; David Kading ; Shane R. Kannarr ; Jason Miller ; Satish Modi ; David Ludwick ; Joseph Tauber ; Sruthi Srinivasan ; Venkiteshwar Manoj Année de publication : 2022 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]dysfonctionnement des glandes de Meibomius
[Thésaurus Mesh]Recherche comparative sur l'efficacité
[Thésaurus Mesh]Syndromes de l'oeil sec
[Thésaurus Mesh]ThérapeutiqueMots-clés : Système de pulsations thermiques Résumé : SIGNIFICANCE: Given the significance of meibomian gland dysfunction subjects in evaporative dry eye, its chronic
and progressive nature, limited promising treatment options, and novel treatment techniques are important. This
randomized clinical study evaluated the noninferiority of SYSTANE iLux with LipiFlow in meibomian gland dysfunction treatment at 12 months.
PURPOSE: This study aimed to demonstrate noninferiority of SYSTANE iLux compared with LipiFlow at 12 months
after single treatment in meibomian gland dysfunction subjects with evaporative dry eye.
METHODS: In this prospective, randomized, multicenter, assessor-masked, parallel-group trial, subjects (N = 236;
aged ≥18 years) with meibomian gland score (MGS) of ≤12 in lower eyelids, noninvasive tear breakup time (NITBUT;
first breakup) of <10 seconds, and Impact of Dry Eye on Everyday Life—Symptom Bother (IDEEL-SB) module score
of >16 were randomized (1:1) to receive SYSTANE iLux (n = 119) or LipiFlow (n = 117). Subjects attended a total
of eight visits, including screening, treatment, and follow-up visits at 2 weeks and at 1, 3, 6, 9, and 12 months/
exit, to evaluate change from baseline in MGS, NITBUT, IDEEL-SB module score, and safety outcomes.
RESULTS: A total of 227 subjects completed the study (mean ± standard deviation age, 57.3 ± 13.8 years). At
12 months, least squares mean change from baseline in MGS was similar between iLux and LipiFlow
(17.4 ± 1.97 vs. 17.8 ± 1.98). Noninferiority of SYSTANE iLux compared with LipiFlow in change from baseline
in MGS (95% lower confidence limit of least squares mean difference, >−5), NITBUT (>−2.5 seconds), and
IDEEL-SB score (95% upper confidence limit, <12) was achieved at all post-treatment visits. No other serious ocular or device-related adverse events were reported.
CONCLUSIONS: The treatment outcomes with SYSTANE iLux were noninferior to LipiFlow during the 12-month
follow-up in subjects with dry eye–associated meibomian gland dysfunction.Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Dry Eye Disease in University-based Clinics in Canada: A Retrospective Chart Review / Etty Bitton in OVS : Optometry & Vision Science, vol. 97, 11 (Novembre 2020)
[article]
in OVS : Optometry & Vision Science > vol. 97, 11 (Novembre 2020)
Titre : Dry Eye Disease in University-based Clinics in Canada: A Retrospective Chart Review Type de document : article de périodique Auteurs : Etty Bitton ; Marian Elder ; Sruthi Srinivasan ; Doerte Luensmann ; Lyndon Jones Année de publication : 2020 Langues : Français (fre) Descripteurs (mots clés) : [Thésaurus Mesh]:S:Syndromes de l'oeil sec:Syndromes de l'oeil sec / diagnostic
[Thésaurus Mesh]Canada
[Thésaurus Mesh]Collecte de données
[Thésaurus Mesh]Syndromes de l'oeil secRésumé : SIGNIFICANCE: Dry eye disease (DED) imposes a substantial burden on patients, which can lead to significant economic consequences for society. We provide insights into the DED patient population and DED diagnostic/ management practices in Canada, which to date have been inadequately addressed in the literature. PURPOSE: The purpose of this study was to describe DED patient demographic/clinical characteristics alongside DED diagnosis/management in university-based optometry clinics in Canada. METHODS: This was a retrospective chart review of nonconcurrent non-Sjögren patients with DED at two university-based optometry clinics in Montreal and Waterloo. Waterloo charts with a diagnosis of DED and all charts from the Montreal dry eye clinic were considered for inclusion. RESULTS: Overall, 200 charts were reviewed. Most patients were female (Montreal, 76%; Waterloo, 72%), and the mean age was 57.2 ± 14.9 years at Montreal and 52.6 ± 20.1 years at Waterloo. Patients commonly reported multiple health conditions (e.g., allergies [Montreal, 44%; Waterloo, 36%]), and high use of systemic nonocular medications was observed (Montreal, 76%; Waterloo, 62%). Clinical signs and symptoms of DED were recorded more often in Montreal patients than in Waterloo patients (e.g., dryness symptoms, 100 vs. 72%; tear breakup time, 100 vs. 60%). Warm compresses (Montreal, 63%; Waterloo, 83%) and artificial tears (Montreal, 94%; Waterloo, 96%) were the most frequently recommended nonmedical treatment and ocular lubricant, respectively. Topical steroids were the most frequently prescribed medications (Montreal, 22%; Waterloo, 21%), with typically three to four different interventions recommended per patient at each clinic. No relationship was found between symptoms and clinical signs or recommended interventions. CONCLUSIONS: This retrospective chart review provided the demographics, clinical characteristics, diagnosis, and management options for DED patients in Canadian university-based optometry clinics. The more comprehensive assessments conducted at Montreal may be beneficial to better monitor the progression of DED and to determine treatment effects over time. Permalink : https://bibliotheque.helb-prigogine.be/opac_css/index.php?lvl=notice_display&id= [article]Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire